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Apart from these modes of action, riboflavin has also been shown to activate specific neuroactive molecules such as vitamin B 6 (which confers neuroprotection based on a role in serotonin production) 73 , homocysteine (which has a double-edged neurological role) 74 and kynurenine involved in glutamate excitotoxicity (i.e., excess of glutamate in neural synapse, resulting in death of neural cells) 75

After a single dose (Day 1), the plasma concentration of NAC increased rapidly in both groups